THE CONTINUING VALUE OF NATURAL PRODUCTS FOR DRUG DISCOVERY
Contenido principal del artículo
Resumen
Natural products are the most consistently successful source of drug leads, both historically and currently. Despite this, the use of natural products in industrial drug discovery has fallen out of
favour. Natural products are likely to continue to be sources of new commercially viable drug leads because the chemical novelty associated with natural products is higher than that of any other source: this is particularly important when searching for lead molecules against newly discovered targets for
which there are no known small molecule leads. Despite the commonly held assumptions, natural products can be a more economical source of chemical diversity compared with synthesis of equivalent numbers of diverse chemicals. Additionally, natural products that are found to be biologically active in assays are generally small molecules with drug-like properties. That is, they are capable of being absorbed and metabolised by the body. Hence, development costs to produce orally active medicines are likely to be much lower than with biotechnological products or with most compounds produced to
date from combinatorial chemistry. Since less than 10% of the world’s biodiversity is reckoned to have been tested for biological activity, many more useful lead compounds are waiting to be discovered from natural products. The challenge is how to access this natural chemical diversity. Several different
strategies are emerging, as will be described in this review.
favour. Natural products are likely to continue to be sources of new commercially viable drug leads because the chemical novelty associated with natural products is higher than that of any other source: this is particularly important when searching for lead molecules against newly discovered targets for
which there are no known small molecule leads. Despite the commonly held assumptions, natural products can be a more economical source of chemical diversity compared with synthesis of equivalent numbers of diverse chemicals. Additionally, natural products that are found to be biologically active in assays are generally small molecules with drug-like properties. That is, they are capable of being absorbed and metabolised by the body. Hence, development costs to produce orally active medicines are likely to be much lower than with biotechnological products or with most compounds produced to
date from combinatorial chemistry. Since less than 10% of the world’s biodiversity is reckoned to have been tested for biological activity, many more useful lead compounds are waiting to be discovered from natural products. The challenge is how to access this natural chemical diversity. Several different
strategies are emerging, as will be described in this review.
Detalles del artículo
Cómo citar
1.
Harvey AL. THE CONTINUING VALUE OF NATURAL PRODUCTS FOR DRUG DISCOVERY. Rev. Salud Anim. [Internet]. 22 de mayo de 2014 [citado 21 de noviembre de 2024];31(1):8. Disponible en: https://revistas.censa.edu.cu/index.php/RSA/article/view/386
Número
Sección
ARTÍCULO RESEÑA
Aquellos autores/as que tengan publicaciones con esta revista, aceptan los términos siguientes:
- Los autores/as conservarán sus derechos de autor y garantizarán a la revista el derecho de primera publicación de su obra, el cual estará simultáneamente sujeto a la Licencia Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) que prohíbe el uso comercial de sus publicaciones y permite a terceros compartir la obra siempre que se indique su autor y la primera publicación en esta revista. Bajo esta licencia el autor será libre de:
- Compartir — copiar y redistribuir el material en cualquier medio o formato
- Adaptar — remezclar, transformar y crear a partir del material
- El licenciador no puede revocar estas libertades mientras cumpla con los términos de la licencia
Bajo las siguientes condiciones:
- Reconocimiento — Debe reconocer adecuadamente la autoría, proporcionar un enlace a la licencia e indicar si se han realizado cambios. Puede hacerlo de cualquier manera razonable, pero no de una manera que sugiera que tiene el apoyo del licenciador o lo recibe por el uso que hace.
- NoComercial — No puede utilizar el material para una finalidad comercial.
- No hay restricciones adicionales — No puede aplicar términos legales o medidas tecnológicas que legalmente restrinjan realizar aquello que la licencia permite.
- Los autores/as podrán adoptar otros acuerdos de licencia no exclusiva de distribución de la versión de la obra publicada (p. ej.: depositarla en un archivo telemático institucional o publicarla en un volumen monográfico) siempre que se indique la publicación inicial en esta revista.
- Se permite y recomienda a los autores/as difundir su obra a través de Internet (p. ej.: en archivos telemáticos institucionales o en su página web) antes y durante el proceso de envío, lo cual puede producir intercambios interesantes y aumentar las citas de la obra publicada. (Véase El efecto del acceso abierto).