Actividad antiviral in vitro del extracto acuoso de corteza de Rhizophora mangle L. y la fracción butanólica contra el virus del Moquillo Canino y el virus del Herpes Bovino Tipo 1

Contenido principal del artículo

Elizabeth de Armas
Alessandra Scagliarini
Mara Battilani
Pastor Alfonso
Evangelina Marrero

Resumen

Actualmente existe una creciente necesidad de nuevas sustancias o metabolitos secundarios a partir de productos naturales con actividad antiviral. El objetivo de este estudio fue determinar la actividad antiviral de Rhizophora mangle L. frente a virus prototipos de ADN y ARN. En este sentido, se evaluó el extracto acuoso de corteza de R. mangle (RMABE) y su fracción butanólica (BF-RMABE) mediante las pruebas de citotoxicidad e inhibición del efecto citopático. De la relación entre estas pruebas se calculó el índice de selectividad. Se demostró, además, actividad antiviral in vitro para RMABE y BF-RMABE frente al virus del moquillo canino (CDV) como prototipo de virus ARN (CI50 83,30 y 86,10 μg/mL, respectivamente) y el Herpes Virus Bovino tipo 1 (BHV-1) como prototipo de ADN (CI50 87,50 y 90,63 μg/mL, respectivamente). Los extractos de R. mangle evaluados, mostraron efecto antiviral, lo que sugiere la necesidad de pruebas adicionales para confirmar su actividad in vivo.

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de Armas, E., Scagliarini, A., Battilani, M., Alfonso, P., & Marrero, E. (2018). Actividad antiviral in vitro del extracto acuoso de corteza de Rhizophora mangle L. y la fracción butanólica contra el virus del Moquillo Canino y el virus del Herpes Bovino Tipo 1. Revista De Salud Animal, 40(1). Recuperado a partir de http://revistas.censa.edu.cu/index.php/RSA/article/view/933
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