Antibacterial activity of silver nanoparticles from Leea coccinea leaves on Staphylococcus aureus
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Abstract
Infections caused by Staphylococcus aureus represent a problem for animal and human health. This work was aimed to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of silver nanoparticles (NpAg) obtained by green synthesis with Leea coccinea leaf extract on Staphylococcus aureus strains and methicillin resistant isolates. Three batches of NpAg from Leea coccinea were evaluated on two S. aureus strains and two methicillin resistant isolates, by the serial dilution method, for MIC and MBC determination. NpAg from Leea coccinea showed antibacterial activity against resistant strains and isolates of S. aureus, with MIC values for the three batches mostly coinciding at 0.03 mg/mL for all the strains and isolates. MBC values in the three batches agreed and differences were observed between the values for resistant isolates (0.485 mg/mL) and strains (0.12 mg/mL). These results demonstrate the antibacterial activity of NpAg from Leea coccinea on this pathogen, demonstrating its potential as an alternative to antibiotic resistance and creating the basis for further studies for its application as an antibacterial agent.
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National Center for Animal and Plant Health (CENSA)References
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