Trend and spatio-temporal clustering of fasciolosis in Granma province, Cuba (2012-2018)
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Abstract
The aim of the present study was to evaluate the trend and presence of spatio-temporal clusters of bovine livers condemned by Fasciola hepatica. Data were collected in a slaughterhouse in Granma province, Cuba, during seven consecutive years (2012 - 2018), totaling 2 555 observations. Descriptive statistical analysis was performed using RStudio and the ggplot2 package to visualize the data. A probabilistic SaTScan™ model was applied to assess whether the findings were spatiotemporally distributed homogeneously. The detection of affected livers peaked over 80 cases weekly, while periods of stability ranged 30 to 40 cases. The overall prevalence of affected livers during the study period was 23.34% (Confidence Interval 0.95, 22.88 - 23.80), although there were significant differences between years. On the other hand, there was a high negative correlation (-0.7857) between the number of cattle slaughtered annually and the prevalence of seized livers. The cases of fasciolosis were not spatiotemporally distributed homogeneously and showed high rates (HR) and low rates (LR) clusters of occurrences in some areas. In total, seven clusters were detected, four of HR and three of LR. The study suggested priority zones for specific interventions related to the identification of protective or risk factors for transmission, while supporting the prioritization of resources for evidence-based prevention and control interventions.
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National Center for Animal and Plant Health (CENSA)References
Charlier J, Rinaldi L, Musella V, Ploeger HW, Chartier C, Vineer HR, et al. Initial assessment of the economic burden of major parasitic helminth infections to the ruminant livestock industry in Europe. Prev Vet Med. 2020 Sep;182:105103.
Castillo-Cuenca, J. C., Iannacone, J., Fimia-Duarte, R., Quiñones-Prieto, M. D. C., Cepero-Rodríguez, O., Yhanes-Santander, C. A., Campos-Cardoso LM. Epidemiologic behavior of fasciolosis in Villa Clara province, Cuba. Neotrop Helminthol. 2016;10(1):23–31.
Palacio Collado D, Bertot Valdés J, Beltrao Molento M, Vázquez Gil Á, Ortíz Vázquez R, Fortune Nápoles CFN. Economic losses and prevalence of Fasciola hepatica in cattle slaughtered in two cuban provinces. Rev MVZ Córdoba. 2019 Dec 19;25(1).
Caravedo MA, Cabada M. Human Fascioliasis: Current Epidemiological Status and Strategies for Diagnosis, Treatment, and Control. Res Rep Trop Med. 2020 Nov;Volume 11:149–58.
Rosas-Hostos Infantes LR, Paredes Yataco GA, Ortiz-Martínez Y, Mayer T, Terashima A, Franco-Paredes C, et al. The global prevalence of human fascioliasis: a systematic review and meta-analysis. Ther Adv Infect Dis. 2023 Jan 8;10.
World Health Organization. Ending the neglect to attain the sustainable development goals: a road map for neglected tropical diseases 2021–2030. [Internet]. WHO. 2020. 196 p. Disponible en: https://apps.who.int/iris/bitstream/handle/10665/338565/9789240010352-eng.pdf?sequence=1
PAHO. Operational guidelines for the elimination of human fascioliasis as a public health problem in the Americas [Internet]. Washington, D.C; 2024. Disponible en: https://doi.org/10.37774/9789275128084
García-Díez J, Saraiva S, Moura D, Grispoldi L, Cenci-Goga BT, Saraiva C. The Importance of the Slaughterhouse in Surveilling Animal and Public Health: A Systematic Review. Vol. 10, Veterinary Sciences. 2023. p. 167.
George J, Häsler B, Mremi I, Sindato C, Mboera L, Rweyemamu M, et al. A systematic review on integration mechanisms in human and animal health surveillance systems with a view to addressing global health security threats. One Heal Outlook. 2020 Dec 8;2(1):11.
Rahman AKMA, Islam SS, Talukder MH, Hassan MK, Dhand NK, Ward MP. Fascioliasis risk factors and space-time clusters in domestic ruminants in Bangladesh. Parasit Vectors. 2017 Dec 8;10(1):228.
Fimia-Duarte R, Aldaz-Cárdenas JW, Alarcón-Elbal PM, Diéguez-Fernández L, Armiñana-García R, Iannacone J, et al. Evolución de las entidades angiostrongilosis y fasciolosis durante los años 2015 y 2016 en la provincia Villa Clara, Cuba. Neotrop Helminthol. 2020 Jun 23;14(1):93–103.
Moustafa MAM, Mohamed WMA, Lau ACC, Chatanga E, Qiu Y, Hayashi N, et al. R A language and environment for statistical computing, R Foundation for Statistical. Computing. 2020;20:1979–92.
Gómez-Rubio V. ggplot2 - Elegant Graphics for Data Analysis (2nd Edition). J Stat Softw [Internet]. 2017;77(Book Review 2). Disponible en: http://www.jstatsoft.org/v77/b02/
Duvergel YC, Miranda I. COMPAPROP: Sistema para comparación de proporciones múltiples. Rev Protección Veg. 2014;29(3):231–4.
Kulldorff M. SaTScanTM user guide for version 9.6. [Internet]. EE. UU; 2018. Disponible en: https://www.satscan.org/
QGIS. QGIS 3.34. Geographic Information System User Guide. [Internet]. QGIS Association. Electronic document; 2024. Disponible en: https://docs.qgis.org/3.34/en/docs/user_manual/index.html
Kurnianto H, Ramanoon SZ, Aziz NAA, Indarjulianto S. Prevalence, risk factors, and infection intensity of fasciolosis in dairy cattle in Boyolali, Indonesia. Vet World. 2022 Jun 12;15(6):1438–48.
José J. Bonet Sánchez, Leonel Lazo Pérez, Rigoberto Fimia Duarte, Pedro Y. de la Fe Rodríguez, María P. Zambrano Gavilanes, Freddy E. Zambrano Gavilanes, et al. Seizures of livers due to fasciolosis in cattle slaughtered in a slaughterhouse in Villa Clara, Cuba. 2016-2020. GSC Adv Res Rev. 2022;12(2):038–45.
Arenal A, García Y, Quesada L, Velázquez D, Sánchez D, Peña M, et al. Risk factors for the presence of Fasciola hepatica antibodies in bulk-milk samples and their association with milk production decreases, in Cuban dairy cattle. BMC Vet Res [Internet]. 2018 Dec 8;14(1):336. Disponible en: https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-018-1654-2
Rotejanaprasert C, Chinpong K, Lawson AB, Chienwichai P, Maude RJ. Evaluation and comparison of spatial cluster detection methods for improved decision making of disease surveillance: a case study of national dengue surveillance in Thailand. BMC Med Res Methodol. 2024;24(1).
Cueva-Rodríguez M, Torrel T, Hobán C, Alvarez-García W, Mejia F, Vargas-Rocha L. Prevalencia de Fasciola hepatica y Calicophoron spp. en vacunos de crianza extensiva del distrito Florida (Amazonas), Perú. Rev Mex Ciencias Pecu [Internet]. 2024 Apr 23;15(2):376–92. Disponible en: https://cienciaspecuarias.inifap.gob.mx/index.php/Pecuarias/article/view/6496
Bargues MD, Artigas P, Angles R, Osca D, Duran P, Buchon P, et al. Genetic uniformity, geographical spread and anthropogenic habitat modifications of lymnaeid vectors found in a One Health initiative in the highest human fascioliasis hyperendemic of the Bolivian Altiplano. Parasit Vectors. 2020 Dec 6;13(1):171.
Nurhidayah N, Satrija F, Retnani EB, Astuti DA, Murtini S. Prevalence and risk factors of trematode infection in swamp buffaloes reared under different agro-climatic conditions in Java Island of Indonesia. Vet World. 2020 Apr 15;13(4):687–94.
Ahmad-Najib M, Wan-Nor-amilah WAW, Kin WW, Arizam MF, Noor-Izani NJ. Prevalence and risk factors of bovine fascioliasis in kelantan, malaysia: A cross-sectional study. Trop Life Sci Res. 2021 Jun 29;32(2):1–14.
Oficina Nacional de Estadística e Información (ONEI). Anuario Estadístico Granma 2020. Edición 2023. Capítulo 7. Agricultura, Ganadería, Silvicultura y Pesca. [Internet]. Granma; 2023. Disponible en: https://www.onei.gob.cu/sites/default/files/publicaciones/2022-03/AEPGranma.pdf
Silva AEP, Freitas C da C, Dutra LV, Molento MB. Correlation between climate data and land altitude for Fasciola hepatica infection in cattle in Santa Catarina, Brazil. Rev Bras Parasitol Veterinária. 2020;29(3):1–7.
Obialigwe T, Pindar H, Uko I, Ekechukwu K. Prevalence of bovine fasciolosis in Jalingo abattoir, Taraba State, Nigeria. Microbes Infect Dis. 2023 Sep 7;5(2):0–0.
Frias H, Maraví C, Arista-Ruiz MA, Yari-Briones DI, Paredes-Valderrama JR, Bravo YR, et al. Prevalence, coinfection, and risk factors associated with Fasciola hepatica and other gastrointestinal parasites in cattle from the Peruvian Amazon. Vet World. 2023 Mar 22;16(3):546–53.
Alba A, Vazquez AA, Hurtrez-Boussès S. Towards the comprehension of fasciolosis (re-)emergence: an integrative overview. Parasitology. 2021 Apr 2;148(4):385–407.
Angles R, Buchon P, Valero MA, Bargues MD, Mas-Coma S. One Health Action against Human Fascioliasis in the Bolivian Altiplano: Food, Water, Housing, Behavioural Traditions, Social Aspects, and Livestock Management Linked to Disease Transmission and Infection Sources. Int J Environ Res Public Health. 2022 Jan 20;19(3):1120.
Sim JXY, Pinto S, van Mourik MSM. Comparing automated surveillance systems for detection of pathogen-related clusters in healthcare settings. Antimicrob Resist Infect Control. 2024 Jun 26;13(1):69.
Valderrama Pomé AA, Merino Trujillo K, Serrano Olivares KJI, Serrano Ramos DH, Gavidia Chucán CM, Quispe Paredes WM. Asociación de fascioliasis con el estado nutricional y coinfección enteroparasitaria en niños. Rev Cubana Med Trop. 2021;73(1)(1):1–18.
Escalona Robaina CR, Álvarez Escobar MDC, Torres Álvarez A, Semper González AI. Fasciolasis hepatica, serie de casos reportados en Matanzas. Cuba. Rev Medica Electron. 2020;42(5):965–80.
Mas-Coma S, Valero MA, Bargues MD. One Health for fascioliasis control in human endemic areas. Trends Parasitol. 2023 Aug;39(8):650–67.
Rodríguez Alarcón A. Caracterización de los pacientes con diagnóstico de Fasciola hepatica atendidos en el IPK; 2018-2019 [Internet]. 2022. Disponible en: https://catalogobibliotecaipk.sld.cu/index.php?P=DownloadFile&Id=378
Carnevale S, Malandrini JB, Pantano ML, Sawicki M, Kamenetzky L, Soria CC, et al. Use of the PCR in a Combined Methodological Approach for the Study of Human Fascioliasis in an Endemic Area. Acta Parasitol. 2021;66(2):455–60.