Combined efficacy of ivermectin and triclabendazole against bovine fasciolosis
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Abstract
This study aimed to evaluate the combined efficacy of triclabendazole (TCBZ) and ivermectin (IVM) against Fasciola hepatica in dairy cattle. Four groups of 15 Holstein cattle were formed: the first was the control (T0); TCBZ (12 mg/kg b.w.) was administered orally in the second (T1); TCBZ, fenbendazole and IVM (12, 10 and 0.2 mg/kg b.w.) were administered orally in the third (T2); and TCBZ (12 mg/kg b.w.) was administered orally and IVM (0.2 mg/kg b.w.) was administered subcutaneously in the fourth group (T3). The efficacy observed was 51.75 % (95 % CI: 42.41 - 61.09) in T1, 56.64 % (95 % CI: 47.42 - 65.86) in T2 and 69.93 % (95 % CI: 61.40 - 78.46) in T3. IVM increased the efficacy of TCBZ by 9.45 % in T2 and 35.13 % in T3 compared to T1. Although the addition of IVM, whether administered orally or subcutaneously, enhanced the efficacy of TCBZ, this combination as a pharmacological control strategy for F. hepatica in dairy cattle in Cajamarca was not encouraging.
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National Center for Animal and Plant Health (CENSA)References
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