In vitro antiviral activity of Rhizophora mangle L. aqueous bark extract and the butanolic fraction against Canine Distemper Virus and Bovine Herpes Virus type 1

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Published: Jun 19, 2018
Keywords:
in vitro antiviral activity, CDV, VHB-1, polyphenols, Rhizophora mangle

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Elizabeth de Armas
Animal Health Direction, National Centre for Animal and Plant Health
Alessandra Scagliarini
Department of Veterinary Medical Science, Alma Mater Studiorum, University of Bologna
Mara Battilani
Department of Veterinary Medical Science, Alma Mater Studiorum, University of Bologna
Pastor Alfonso
Animal Health Direction, National Centre for Animal and Plant Health
Evangelina Marrero
Animal Health Direction, National Centre for Animal and Plant Health

Abstract

There is currently an increasing need for new substances or secondary metabolites from natural products with antiviral activity. The aim of this study was to determine the antiviral activity of Rhizophora mangle L. against DNA and RNA virus. With this aim, R. mangle aqueous bark extract (RMABE) and its butanolic fraction (BF-RMABE) were evaluated for the cytotoxicity and cytopathic effect inhibition assay. The selectivity index was also calculated. An in vitro antiviral activity was demonstrated for RMABE and BF-RMABE against the RNA prototype of Canine Distemper Virus (CDV) (CI50 83.30 and 86.10 μg/mL, respectively) and the DNA prototype of Bovine Herpes Virus type 1 (BHV-1) (CI50 87.50 and 90.63 μg/mL, respectively). The results showed the promising antiviral effect of the evaluated R. mangle extracts, suggesting the need for further tests to confirm itsin vivo activity.

Article Details

How to Cite
1.
de Armas E, Scagliarini A, Battilani M, Alfonso P, Marrero E. In vitro antiviral activity of Rhizophora mangle L. aqueous bark extract and the butanolic fraction against Canine Distemper Virus and Bovine Herpes Virus type 1. Rev. Salud Anim. [Internet]. 2018 Jun. 19 [cited 2024 Nov. 24];40(1). Available from: https://revistas.censa.edu.cu/index.php/RSA/article/view/933
Issue
Vol. 40 No. 1 (2018): enero-abril
Section
ARTÍCULOS ORIGINALES
National Center for Animal and Plant Health (CENSA)

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